These Unwanted effects may be more possible after you very first start out using dihydrocodeine but could materialize at any time, one example is, when setting up An additional medication or if a doctor improves your dose.
Hyponatremia: Clinically significant hyponatremia (sodium 3 periods the higher limit of standard) to scarce cases with concomitant elevations of whole bilirubin (>two moments the higher limit of normal) are actually noted with APTIOM use.
Use Warning/Check. Ethinyl estradiol may possibly inhibit the clearance of benzodiazepines that undergo oxidation, therefore increasing serum concentrations of concomitantly administered benzodiazepines.
stiripentol will decrease the level or result of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Observe Closely. Contemplate lowering the dose of CYP2C19 substrates, if adverse reactions are professional when administered concomitantly with stiripentol.
cenobamate will raise the degree or impact of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep track of Carefully. Take into consideration a dose reduction of CYP2C19 substrates, as clinically ideal, when made use of concomitantly with cenobamate.
Speak with a doctor or pharmacist should you be Uncertain irrespective of whether It really is Safe and sound that you should travel even though getting dihydrocodeine. GOV.United kingdom has far more details about the law on drugs and driving.
Antegrade amnesia could manifest making use of therapeutic dosages, the risk increasing at bigger dosages; amnestic outcomes could be connected with inappropriate actions
Advise individuals to avoid driving or working weighty equipment until eventually affected person is aware of the effects from the drug
Steer clear of or substitute A further drug for these medicines when doable. Consider for lack of therapeutic effect if medication need to be coadministered. Regulate dose according to prescribing information and facts if required.
danazol will improve the degree or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Cessation of benzodiazepines or other CNS depressants is preferred most often. Sometimes, monitoring at an increased degree of care for tapering CNS depressants could possibly be acceptable. In Other folks, progressively tapering a patient off of a prescribed benzodiazepine or other CNS depressant or reducing to the bottom successful dose may be ideal.
zafirlukast will improve the amount or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
dexamethasone will lessen the extent or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
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